Welcome to the Shen Lab!
Researching Fundamental Elements and Mechanisms in Neurobiology
Our lab studies fundamental cell biology questions in the nervous system. These questions include how neurons establish polarized cytoskeletal networks during development, how polarized intracellular membrane trafficking gives rise to distinct morphology and function of axon and dendrites, how neurons coordinate intracellular synaptic assembly and extracellular signaling events to form specific synaptic connections at particular subcellular locations, with appropriate size and density. We are working on these questions in the simple nervous system of nematode Caenorhabditis elegans, which enables us to study cell biology in live neurons in their natural environments. Explore our site to learn more about us!
Liang et. al 2020. Video 1 - EBP-2::GFP comets reveal an MTOC in the outgrowing anterior dendrite growth cone of a wt PVD neuron in C. elegans.
C. elegans on an Agar Plate.
Shen Lab Dinner, April 2024
Human iPSC-derived cortical neurons transfected with GFP.
GFP-Labeled EBP-2 Dynamic In A Developing Primary Dendrite.
Diversity: Many Genes, One Lab
Our lab is committed to creating an inclusive environment where people from different backgrounds and experiences can collaborate, contribute, and succeed. We greatly respect and value every individual, actively fostering a culture that is open and equal, supporting each other in our research and everyday life. We believe that diversity is essential to science. We welcome collaboration and effort with diverse groups, especially as these perspectives strengthen our sense of community and may lead to new insights and advancements.
In our lab, everyone belongs, and every contribution matters.
