Publications
Shi et al 2021. Figure 2A-C, E.
Spotlight: A two-step actin polymerization mechanism drives dendrite branching.
Spotlight: A two-step actin polymerization mechanism drives dendrite branching.
"[In] the C. elegans PVD neuron, the development of dendritic arbors requires two distinct, but cooperative, steps of actin assembly that involve the WRC, UNC-34 (Ena/VASP), and the actin-binding protein UNC-115 (abLIM)... Here, we show that new dendrite branch points are established first as local “swellings” along dendrites, from which filopodia sprout to enable rapid and efficient outgrowth of dendritic branches."
Listed Publications
2023
(9)
McDonald NA, Tao L, Dong MQ, Shen K. SAD-1 kinase controls presynaptic phase separatioan by relieving SYD-2/Liprin-α autoinhibition. PLoS Biol. 2023 Dec 4;21(12):e3002421. doi: 10.1371/journal.pbio.3002421.
Medwig-Kinney TN, Kinney BA, Martinez MAQ, Yee C, Sirota SS, Mullarkey AA, Somineni N, Hippler J, Zhang W, Shen K, Hammell C, Pani AM, Matus DQ. Dynamic compartmentalization of the pro-invasive transcription factor NHR-67 reveals a role for Groucho in regulating a proliferative-invasive cellular switch in C. elegans. Elife. 2023 Dec 1;12:RP84355. doi: 10.7554/eLife.84355.
Tzeng CP, Shen K. Wnt signaling and contact-mediated repulsion shape sensory dendritic fields. bioRxiv [Preprint]. 2023 Sep 15:2023.09.14.557812. doi: 10.1101/2023.09.14.557812.
Xie J, Zou W, Tugizova M, Shen K, Wang X. MBL-1 and EEL-1 affect the splicing and protein levels of MEC-3 to control dendrite complexity. PLoS Genet. 2023 Sep 20;19(9):e1010941. doi: 10.1371/journal.pgen.1010941.
Land R, Fetter R, Liang X, Tzeng CP, Taylor CA, Shen K. Endoplasmic Reticulum Exit Sites scale with somato-dendritic size in neurons. Mol Biol Cell. 2023 Oct 1;34(11):ar106. doi: 10.1091/mbc.E23-03-0090.
Kramer DA, Narvaez-Ortiz HY, Patel U, Shi R, Shen K, Nolen BJ, Roche J, Chen B. The intrinsically disordered cytoplasmic tail of a dendrite branching receptor uses two distinct mechanisms to regulate the actin cytoskeleton. Elife. 2023 Aug 9;12:e88492. doi: 10.7554/eLife.88492.
Tran MV, Ferguson JW, Cote LE, Khuntsariya D, Fetter RD, Wang JT, Wellard SR, Sallee MD, Genova M, Eskinazi S, Magiera MM, Janke C, Stearns T, Lansky Z, Shen K, Magescas J, Feldman JL. MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement. bioRxiv [Preprint]. 2023 Feb 23:2023.02.23.529616. doi: 10.1101/2023.02.23.529616. Update in: Dev Cell. 2024 Jan 22;59(2):199-210.e11. doi: 10.1016/j.devcel.2023.12.001.
Pandey T, Wang B, Wang C, Zu J, Deng H, Shen K, do Vale GD, McDonald JG, Ma DK. LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans. bioRxiv [Preprint]. 2023 Jul 17:2023.02.14.528431. doi: 10.1101/2023.02.14.528431. Update in: Cell Rep. 2024 Mar 26;43(3):113899. doi: 10.1016/j.celrep.2024.113899. PMID: 36824874; PMCID: PMC9949100.
Xiao Y, Yee C, Zhao CZ, Martinez MAQ, Zhang W, Shen K, Matus DQ, Hammell C. An expandable FLP-ON::TIR1 system for precise spatiotemporal protein degradation in Caenorhabditis elegans. Genetics. 2023 Apr 6;223(4):iyad013. doi: 10.1093/genetics/iyad013. PMID: 36722258; PMCID: PMC10319979.
2022
(5)
Martinez MAQ, Mullarkey AA, Yee C, Zhao CZ, Zhang W, Shen K, Matus DQ. Reevaluating the relationship between EGL-43 (EVI1) and LIN-12 (Notch) during C. elegans anchor cell invasion. Biol Open. 2022 Dec 15;11(12):bio059668. doi: 10.1242/bio.059668.
Wang C, Wang B, Pandey T, Long Y, Zhang J, Oh F, Sima J, Guo R, Liu Y, Zhang C, Mukherjee S, Bassik M, Lin W, Deng H, Vale G, McDonald JG, Shen K, Ma DK. A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience. Nat Commun. 2022 Nov 10;13(1):6805. doi: 10.1038/s41467-022-34450-y.
Suzuki N, Zou Y, Sun H, Eichel K, Shao M, Shih M, Shen K, Chang C. Two intrinsic timing mechanisms set start and end times for dendritic arborization of a nociceptive neuron. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2210053119. doi: 10.1073/pnas.2210053119.
Eichel K, Uenaka T, Belapurkar V, Lu R, Cheng S, Pak JS, Taylor CA, Südhof TC, Malenka R, Wernig M, Özkan E, Perrais D, Shen K. Endocytosis in the axon initial segment maintains neuronal polarity. Nature. 2022 Sep;609(7925):128-135. doi: 10.1038/s41586-022-05074-5.
Tao L, Coakley S, Shi R, Shen K. Dendrites use mechanosensitive channels to proofread ligand-mediated neurite extension during morphogenesis. Dev Cell. 2022 Jul 11;57(13):1615-1629.e3. doi: 10.1016/j.devcel.2022.05.019.
2021
(4)
Deng H, Qiao X, Xie T, Fu W, Li H, Zhao Y, Guo M, Feng Y, Chen L, Zhao Y, Miao L, Chen C, Shen K, Wang X. SLC-30A9 is required for Zn2+ homeostasis, Zn2+ mobilization, and mitochondrial health. Proc Natl Acad Sci U S A. 2021 Aug 31;118(35):e2023909118. doi: 10.1073/pnas.2023909118.
Shi R, Kramer DA, Chen B, Shen K. A two-step actin polymerization mechanism drives dendrite branching. Neural Dev. 2021 Jul 19;16(1):3. doi: 10.1186/s13064-021-00154-0.
Sanchez AD, Branon TC, Cote LE, Papagiannakis A, Liang X, Pickett MA, Shen K, Jacobs-Wagner C, Ting AY, Feldman JL. Proximity labeling reveals non-centrosomal microtubule-organizing center components required for microtubule growth and localization. Curr Biol. 2021 Aug 23;31(16):3586-3600.e11. doi: 10.1016/j.cub.2021.06.021.
Zhao Y, Song E, Wang W, Hsieh CH, Wang X, Feng W, Wang X, Shen K. Metaxins are core components of mitochondrial transport adaptor complexes. Nat Commun. 2021 Jan 4;12(1):83. doi: 10.1038/s41467-020-20346-2.
2020
(3)
McDonald NA, Fetter RD, Shen K. Assembly of synaptic active zones requires phase separation of scaffold molecules. Nature. 2020 Dec;588(7838):454-458. doi: 10.1038/s41586-020-2942-0. Epub 2020 Nov 18. Erratum in: Nature. 2021 Jul;595(7866):E35. doi: 10.1038/s41586-021-03340-6.
Liang X, Kokes M, Fetter RD, Sallee MD, Moore AW, Feldman JL, Shen K. Growth cone-localized microtubule organizing center establishes microtubule orientation in dendrites. Elife. 2020 Jul 13;9:e56547. doi: 10.7554/eLife.56547.
Liu J, Kim YS, Richardson CE, Tom A, Ramakrishnan C, Birey F, Katsumata T, Chen S, Wang C, Wang X, Joubert LM, Jiang Y, Wang H, Fenno LE, Tok JB, Pașca SP, Shen K, Bao Z, Deisseroth K. Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals. Science. 2020 Mar 20;367(6484):1372-1376. doi: 10.1126/science.aay4866.
2019
(5)
Tao L, Porto D, Li Z, Fechner S, Lee SA, Goodman MB, Xu XZS, Lu H, Shen K. Parallel Processing of Two Mechanosensory Modalities by a Single Neuron in C. elegans. Dev Cell. 2019 Dec 2;51(5):617-631.e3. doi: 10.1016/j.devcel.2019.10.008.
Richardson CE, Yee C, Shen K. A hormone receptor pathway cell-autonomously delays neuron morphological aging by suppressing endocytosis. PLoS Biol. 2019 Oct 7;17(10):e3000452. doi: 10.1371/journal.pbio.3000452.
Lee J, Taylor CA, Barnes KM, Shen A, Stewart EV, Chen A, Xiang YK, Bao Z, Shen K. A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes. Elife. 2019 Aug 6;8:e46703. doi: 10.7554/eLife.46703.
Richardson CE, Shen K. Neurite Development and Repair in Worms and Flies. Annu Rev Neurosci. 2019 Jul 8;42:209-226. doi: 10.1146/annurev-neuro-070918-050208.
Liu X, Guo X, Niu L, Li X, Sun F, Hu J, Wang X, Shen K. Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites. Nat Commun. 2019 Feb 4;10(1):568. doi: 10.1038/s41467-019-08478-6.
2018
(6)
Kurshan PT, Merrill SA, Dong Y, Ding C, Hammarlund M, Bai J, Jorgensen EM, Shen K. γ-Neurexin and Frizzled Mediate Parallel Synapse Assembly Pathways Antagonized by Receptor Endocytosis. Neuron. 2018 Oct 10;100(1):150-166.e4. doi: 10.1016/j.neuron.2018.09.007.
Lipton DM, Maeder CI, Shen K. Rapid Assembly of Presynaptic Materials behind the Growth Cone in Dopaminergic Neurons Is Mediated by Precise Regulation of Axonal Transport. Cell Rep. 2018 Sep 4;24(10):2709-2722. doi: 10.1016/j.celrep.2018.07.096.
Kato HE, Kim YS, Paggi JM, Evans KE, Allen WE, Richardson C, Inoue K, Ito S, Ramakrishnan C, Fenno LE, Yamashita K, Hilger D, Lee SY, Berndt A, Shen K, Kandori H, Dror RO, Kobilka BK, Deisseroth K. Structural mechanisms of selectivity and gating in anion channelrhodopsins. Nature. 2018 Sep;561(7723):349-354. doi: 10.1038/s41586-018-0504-5.
Maeder CI, Kim JI, Liang X, Kaganovsky K, Shen A, Li Q, Li Z, Wang S, Xu XZS, Li JB, Xiang YK, Ding JB, Shen K. The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival. Cell. 2018 Sep 6;174(6):1436-1449.e20. doi: 10.1016/j.cell.2018.07.046.
Dong R, Zhu T, Benedetti L, Gowrishankar S, Deng H, Cai Y, Wang X, Shen K, De Camilli P. The inositol 5-phosphatase INPP5K participates in the fine control of ER organization. J Cell Biol. 2018 Oct 1;217(10):3577-3592. doi: 10.1083/jcb.201802125.
Zou W, Dong X, Broederdorf TR, Shen A, Kramer DA, Shi R, Liang X, Miller DM 3rd, Xiang YK, Yasuda R, Chen B, Shen K. A Dendritic Guidance Receptor Complex Brings Together Distinct Actin Regulators to Drive Efficient F-Actin Assembly and Branching. Dev Cell. 2018 May 7;45(3):362-375.e3. doi: 10.1016/j.devcel.2018.04.008.
2017
(6)
Xuan Z, Manning L, Nelson J, Richmond JE, Colón-Ramos DA, Shen K, Kurshan PT. Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release. Elife. 2017 Nov 21;6:e29276. doi: 10.7554/eLife.29276.
Zhu T, Liang X, Wang XM, Shen K. Dynein and EFF-1 control dendrite morphology by regulating the localization pattern of SAX-7 in epidermal cells. J Cell Sci. 2017 Dec 1;130(23):4063-4071. doi: 10.1242/jcs.201699.
Niwa S, Tao L, Lu SY, Liew GM, Feng W, Nachury MV, Shen K. BORC Regulates the Axonal Transport of Synaptic Vesicle Precursors by Activating ARL-8. Curr Biol. 2017 Sep 11;27(17):2569-2578.e4. doi: 10.1016/j.cub.2017.07.013.
Yogev S, Maeder CI, Cooper R, Horowitz M, Hendricks AG, Shen K. Local inhibition of microtubule dynamics by dynein is required for neuronal cargo distribution. Nat Commun. 2017 Apr 13;8:15063. doi: 10.1038/ncomms15063.
Zhou XX, Fan LZ, Li P, Shen K, Lin MZ. Optical control of cell signaling by single-chain photoswitchable kinases. Science. 2017 Feb 24;355(6327):836-842. doi: 10.1126/science.aah3605.
Krieg M, Stühmer J, Cueva JG, Fetter R, Spilker K, Cremers D, Shen K, Dunn AR, Goodman MB. Genetic defects in β-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling. Elife. 2017 Jan 18;6:e20172. doi: 10.7554/eLife.20172.
2016
(10)
San-Miguel A, Kurshan PT, Crane MM, Zhao Y, McGrath PT, Shen K, Lu H. Deep phenotyping unveils hidden traits and genetic relations in subtle mutants. Nat Commun. 2016 Nov 23;7:12990. doi: 10.1038/ncomms12990.
Zou W, Shen A, Dong X, Tugizova M, Xiang YK, Shen K. A multi-protein receptor-ligand complex underlies combinatorial dendrite guidance choices in C. elegans. Elife. 2016 Oct 5;5:e18345. doi: 10.7554/eLife.18345.
Yogev S, Cooper R, Fetter R, Horowitz M, Shen K. Microtubule Organization Determines Axonal Transport Dynamics. Neuron. 2016 Oct 19;92(2):449-460. doi: 10.1016/j.neuron.2016.09.036.
Niwa S, Lipton DM, Morikawa M, Zhao C, Hirokawa N, Lu H, Shen K. Autoinhibition of a Neuronal Kinesin UNC-104/KIF1A Regulates the Size and Density of Synapses. Cell Rep. 2016 Aug 23;16(8):2129-2141. doi: 10.1016/j.celrep.2016.07.043.
He J, Zhou R, Wu Z, Carrasco MA, Kurshan PT, Farley JE, Simon DJ, Wang G, Han B, Hao J, Heller E, Freeman MR, Shen K, Maniatis T, Tessier-Lavigne M, Zhuang X. Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species. Proc Natl Acad Sci U S A. 2016 May 24;113(21):6029-34. doi: 10.1073/pnas.1605707113.
Li P, Merrill SA, Jorgensen EM, Shen K. Two Clathrin Adaptor Protein Complexes Instruct Axon-Dendrite Polarity. Neuron. 2016 May 4;90(3):564-80. doi: 10.1016/j.neuron.2016.04.020.
Dong X, Chiu H, Park YJ, Zou W, Zou Y, Özkan E, Chang C, Shen K. Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions. Elife. 2016 Mar 14;5:e11008. doi: 10.7554/eLife.11008.
Liu X, Wang X, Shen K. Receptor tyrosine phosphatase CLR-1 acts in skin cells to promote sensory dendrite outgrowth. Dev Biol. 2016 May 1;413(1):60-9. doi: 10.1016/j.ydbio.2016.03.001.
Li LB, Lei H, Arey RN, Li P, Liu J, Murphy CT, Xu XZ, Shen K. The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory. Curr Biol. 2016 Mar 7;26(5):605-15. doi: 10.1016/j.cub.2015.12.068.
Zhou X, Zeng J, Ouyang C, Luo Q, Yu M, Yang Z, Wang H, Shen K, Shi A. A novel bipartite UNC-101/AP-1 μ1 binding signal mediates KVS-4/Kv2.1 somatodendritic distribution in Caenorhabditis elegans. FEBS Lett. 2016 Jan;590(1):76-92. doi: 10.1002/1873-3468.12043.
2015
(7)
Zhou X, Zeng J, Ouyang C, Luo Q, Yu M, Yang Z, Wang H, Shen K, Shi A. A novel bipartite UNC-101/AP-1 μ1 binding signal mediates KVS-4/Kv2.1 somatodendritic distribution in Caenorhabditis elegans. FEBS Lett. 2016 Jan;590(1):76-92. doi: 10.1002/1873-3468.12043.
Taylor CA, Yan J, Howell AS, Dong X, Shen K. RAB-10 Regulates Dendritic Branching by Balancing Dendritic Transport. PLoS Genet. 2015 Dec 3;11(12):e1005695. doi: 10.1371/journal.pgen.1005695.
Wei X, Howell AS, Dong X, Taylor CA, Cooper RC, Zhang J, Zou W, Sherwood DR, Shen K. The unfolded protein response is required for dendrite morphogenesis. Elife. 2015 Jun 8;4:e06963. doi: 10.7554/eLife.06963.
Maro GS, Gao S, Olechwier AM, Hung WL, Liu M, Özkan E, Zhen M, Shen K. MADD-4/Punctin and Neurexin Organize C. elegans GABAergic Postsynapses through Neuroligin. Neuron. 2015 Jun 17;86(6):1420-32. doi: 10.1016/j.neuron.2015.05.015.
Liang X, Dong X, Moerman DG, Shen K, Wang X. Sarcomeres Pattern Proprioceptive Sensory Dendritic Endings through UNC-52/Perlecan in C. elegans. Dev Cell. 2015 May 26;33(4):388-400. doi: 10.1016/j.devcel.2015.03.010.
Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD. Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein. Neuron. 2015 Jan 7;85(1):76-87. doi: 10.1016/j.neuron.2014.11.027. Epub 2014 Dec 18. Erratum in: Neuron. 2015 Feb 4;85(3):657. Erratum in: Neuron. 2023 Jan 4;111(1):138. doi: 10.1016/j.neuron.2022.12.020.
Dong X, Shen K, Bülow HE. Intrinsic and extrinsic mechanisms of dendritic morphogenesis. Annu Rev Physiol. 2015;77:271-300. doi: 10.1146/annurev-physiol-021014-071746.
2014
(9)
Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD. Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein. Neuron. 2015 Jan 7;85(1):76-87. doi: 10.1016/j.neuron.2014.11.027. Epub 2014 Dec 18. Erratum in: Neuron. 2015 Feb 4;85(3):657. Erratum in: Neuron. 2023 Jan 4;111(1):138. doi: 10.1016/j.neuron.2022.12.020.
Ericson VR, Spilker KA, Tugizova MS, Shen K. MTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegans. PLoS One. 2014 Dec 5;9(12):e114501. doi: 10.1371/journal.pone.0114501.
Dong X, Shen K, Bülow HE. Intrinsic and extrinsic mechanisms of dendritic morphogenesis. Annu Rev Physiol. 2015;77:271-300. doi: 10.1146/annurev-physiol-021014-071746.
Kurshan PT, Phan AQ, Wang GJ, Crane MM, Lu H, Shen K. Regulation of synaptic extracellular matrix composition is critical for proper synapse morphology. J Neurosci. 2014 Sep 17;34(38):12678-89. doi: 10.1523/JNEUROSCI.1183-14.2014.
Yogev S, Shen K. Cellular and molecular mechanisms of synaptic specificity. Annu Rev Cell Dev Biol. 2014;30:417-37. doi: 10.1146/annurev-cellbio-100913-012953.
Richardson CE, Spilker KA, Cueva JG, Perrino J, Goodman MB, Shen K. PTRN-1, a microtubule minus end-binding CAMSAP homolog, promotes microtubule function in Caenorhabditis elegans neurons. Elife. 2014 Feb 25;3:e01498. doi: 10.7554/eLife.01498.
Özkan E, Chia PH, Wang RR, Goriatcheva N, Borek D, Otwinowski Z, Walz T, Shen K, Garcia KC. Extracellular architecture of the SYG-1/SYG-2 adhesion complex instructs synaptogenesis. Cell. 2014 Jan 30;156(3):482-94. doi: 10.1016/j.cell.2014.01.004.
Chia PH, Chen B, Li P, Rosen MK, Shen K. Local F-actin network links synapse formation and axon branching. Cell. 2014 Jan 16;156(1-2):208-20. doi: 10.1016/j.cell.2013.12.009.
Maeder CI, San-Miguel A, Wu EY, Lu H, Shen K. In vivo neuron-wide analysis of synaptic vesicle precursor trafficking. Traffic. 2014 Mar;15(3):273-91. doi: 10.1111/tra.12142.
2013
(7)
Mizumoto K, Shen K. Two Wnts instruct topographic synaptic innervation in C. elegans. Cell Rep. 2013 Oct 31;5(2):389-96. doi: 10.1016/j.celrep.2013.09.011.
Dong X, Liu OW, Howell AS, Shen K. An extracellular adhesion molecule complex patterns dendritic branching and morphogenesis. Cell. 2013 Oct 10;155(2):296-307. doi: 10.1016/j.cell.2013.08.059.
Wu YE, Huo L, Maeder CI, Feng W, Shen K. The balance between capture and dissociation of presynaptic proteins controls the spatial distribution of synapses. Neuron. 2013 Jun 19;78(6):994-1011. doi: 10.1016/j.neuron.2013.04.035.
Chia PH, Patel MR, Wagner OI, Klopfenstein DR, Shen K. Intramolecular regulation of presynaptic scaffold protein SYD-2/liprin-α. Mol Cell Neurosci. 2013 Sep;56:76-84. doi: 10.1016/j.mcn.2013.03.004.
Li P, Collins KM, Koelle MR, Shen K. LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans. Elife. 2013 Mar 19;2:e00378. doi: 10.7554/eLife.00378.
Yan J, Chao DL, Toba S, Koyasako K, Yasunaga T, Hirotsune S, Shen K. Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans. Elife. 2013 Mar 6;2:e00133. doi: 10.7554/eLife.00133.
Mizumoto K, Shen K. Interaxonal interaction defines tiled presynaptic innervation in C. elegans. Neuron. 2013 Feb 20;77(4):655-66. doi: 10.1016/j.neuron.2012.12.031.
2012
(4)
Crane MM, Stirman JN, Ou CY, Kurshan PT, Rehg JM, Shen K, Lu H. Autonomous screening of C. elegans identifies genes implicated in synaptogenesis. Nat Methods. 2012 Oct;9(10):977-80. doi: 10.1038/nmeth.2141.
Wei X, Potter CJ, Luo L, Shen K. Controlling gene expression with the Q repressible binary expression system in Caenorhabditis elegans. Nat Methods. 2012 Mar 11;9(4):391-5. doi: 10.1038/nmeth.1929.
Spilker KA, Wang GJ, Tugizova MS, Shen K. Caenorhabditis elegans Muscleblind homolog mbl-1 functions in neurons to regulate synapse formation. Neural Dev. 2012 Feb 7;7:7. doi: 10.1186/1749-8104-7-7.
Chia PH, Patel MR, Shen K. NAB-1 instructs synapse assembly by linking adhesion molecules and F-actin to active zone proteins. Nat Neurosci. 2012 Jan 8;15(2):234-42. doi: 10.1038/nn.2991.
2011
(6)
Liu OW, Shen K. The transmembrane LRR protein DMA-1 promotes dendrite branching and growth in C. elegans. Nat Neurosci. 2011 Dec 4;15(1):57-63. doi: 10.1038/nn.2978.
Maniar TA, Kaplan M, Wang GJ, Shen K, Wei L, Shaw JE, Koushika SP, Bargmann CI. UNC-33 (CRMP) and ankyrin organize microtubules and localize kinesin to polarize axon-dendrite sorting. Nat Neurosci. 2011 Nov 20;15(1):48-56. doi: 10.1038/nn.2970.
Hellman AB, Shen K. Sensory transduction channel subunits, tax-4 and tax-2, modify presynaptic molecular architecture in C. elegans. PLoS One. 2011;6(9):e24562. doi: 10.1371/journal.pone.0024562.
Park M, Watanabe S, Poon VY, Ou CY, Jorgensen EM, Shen K. CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits. Neuron. 2011 May 26;70(4):742-57. doi: 10.1016/j.neuron.2011.04.002.
Ou CY, Shen K. Neuronal polarity in C. elegans. Dev Neurobiol. 2011 Jun;71(6):554-66. doi: 10.1002/dneu.20858.
Teichmann HM, Shen K. UNC-6 and UNC-40 promote dendritic growth through PAR-4 in Caenorhabditis elegans neurons. Nat Neurosci. 2011 Feb;14(2):165-72. doi: 10.1038/nn.2717.
2010
(5)
Teichmann HM, Shen K. UNC-6 and UNC-40 promote dendritic growth through PAR-4 in Caenorhabditis elegans neurons. Nat Neurosci. 2011 Feb;14(2):165-72. doi: 10.1038/nn.2717.
Ha HI, Hendricks M, Shen Y, Gabel CV, Fang-Yen C, Qin Y, Colón-Ramos D, Shen K, Samuel AD, Zhang Y. Functional organization of a neural network for aversive olfactory learning in Caenorhabditis elegans. Neuron. 2010 Dec 22;68(6):1173-86. doi: 10.1016/j.neuron.2010.11.025.
Wang GJ, Kang L, Kim JE, Maro GS, Xu XZ, Shen K. GRLD-1 regulates cell-wide abundance of glutamate receptor through post-transcriptional regulation. Nat Neurosci. 2010 Dec;13(12):1489-95. doi: 10.1038/nn.2667.
Klassen MP, Wu YE, Maeder CI, Nakae I, Cueva JG, Lehrman EK, Tada M, Gengyo-Ando K, Wang GJ, Goodman M, Mitani S, Kontani K, Katada T, Shen K. An Arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation. Neuron. 2010 Jun 10;66(5):710-23. doi: 10.1016/j.neuron.2010.04.033.
Ou CY, Poon VY, Maeder CI, Watanabe S, Lehrman EK, Fu AK, Park M, Fu WY, Jorgensen EM, Ip NY, Shen K. Two cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components. Cell. 2010 May 28;141(5):846-58. doi: 10.1016/j.cell.2010.04.011.
2009
(4)
Patel MR, Shen K. Neurite extension: starting at the finish line. Cell. 2009 Apr 17;137(2):207-9. doi: 10.1016/j.cell.2009.04.001.
Patel MR, Shen K. RSY-1 is a local inhibitor of presynaptic assembly in C. elegans. Science. 2009 Mar 13;323(5920):1500-3. doi: 10.1126/science.1169025.
Maro GS, Klassen MP, Shen K. A beta-catenin-dependent Wnt pathway mediates anteroposterior axon guidance in C. elegans motor neurons. PLoS One. 2009;4(3):e4690. doi: 10.1371/journal.pone.0004690.
Margeta MA, Wang GJ, Shen K. Clathrin adaptor AP-1 complex excludes multiple postsynaptic receptors from axons in C. elegans. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1632-7. doi: 10.1073/pnas.0812078106.
2008
(6)
Ding M, Shen K. The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases. Bioessays. 2008 Nov;30(11-12):1075-83. doi: 10.1002/bies.20843.
Poon VY, Klassen MP, Shen K. UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites. Nature. 2008 Oct 2;455(7213):669-73. doi: 10.1038/nature07291.
Chao DL, Shen K. Functional dissection of SYG-1 and SYG-2, cell adhesion molecules required for selective synaptogenesis in C. elegans. Mol Cell Neurosci. 2008 Oct;39(2):248-57. doi: 10.1016/j.mcn.2008.07.001.
Allen PB, Sgro AE, Chao DL, Doepker BE, Scott Edgar J, Shen K, Chiu DT. Single-synapse ablation and long-term imaging in live C. elegans. J Neurosci Methods. 2008 Aug 15;173(1):20-6. doi: 10.1016/j.jneumeth.2008.05.007.
Margeta MA, Shen K, Grill B. Building a synapse: lessons on synaptic specificity and presynaptic assembly from the nematode C. elegans. Curr Opin Neurobiol. 2008 Feb;18(1):69-76. doi: 10.1016/j.conb.2008.04.003.
Feinberg EH, Vanhoven MK, Bendesky A, Wang G, Fetter RD, Shen K, Bargmann CI. GFP Reconstitution Across Synaptic Partners (GRASP) defines cell contacts and synapses in living nervous systems. Neuron. 2008 Feb 7;57(3):353-63. doi: 10.1016/j.neuron.2007.11.030.
2007
(3)
Colón-Ramos DA, Margeta MA, Shen K. Glia promote local synaptogenesis through UNC-6 (netrin) signaling in C. elegans. Science. 2007 Oct 5;318(5847):103-6. doi: 10.1126/science.1143762.
Klassen MP, Shen K. Wnt signaling positions neuromuscular connectivity by inhibiting synapse formation in C. elegans. Cell. 2007 Aug 24;130(4):704-16. doi: 10.1016/j.cell.2007.06.046.
Ding M, Chao D, Wang G, Shen K. Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination. Science. 2007 Aug 17;317(5840):947-51. doi: 10.1126/science.1145727.
2006
(1)
Patel MR, Lehrman EK, Poon VY, Crump JG, Zhen M, Bargmann CI, Shen K. Hierarchical assembly of presynaptic components in defined C. elegans synapses. Nat Neurosci. 2006 Dec;9(12):1488-98. doi: 10.1038/nn1806.
2004
(1)
Shen K, Fetter RD, Bargmann CI. Synaptic specificity is generated by the synaptic guidepost protein SYG-2 and its receptor, SYG-1. Cell. 2004 Mar 19;116(6):869-81. doi: 10.1016/s0092-8674(04)00251-x. Erratum in: Cell.2004 May 14;117(4):553.
2003
(1)
Shen K, Bargmann CI. The immunoglobulin superfamily protein SYG-1 determines the location of specific synapses in C. elegans. Cell. 2003 Mar 7;112(5):619-30. doi: 10.1016/s0092-8674(03)00113-2.
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